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 Table of Contents    
Year : 2011  |  Volume : 4  |  Issue : 2  |  Page : 49  

Genetics of myopia

Department of Ophthalmology, Al Ahli Hospital, Doha, Qatar

Date of Web Publication10-Aug-2011

Correspondence Address:
Alexander A Bialasiewicz
Department of Ophthalmology, Al Ahli Hospital, Doha
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-620X.83652

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How to cite this article:
Bialasiewicz AA. Genetics of myopia. Oman J Ophthalmol 2011;4:49

How to cite this URL:
Bialasiewicz AA. Genetics of myopia. Oman J Ophthalmol [serial online] 2011 [cited 2023 Mar 27];4:49. Available from: https://www.ojoonline.org/text.asp?2011/4/2/49/83652

Myopia research and correction is a World Health Organization priority, because myopia development seems to be attributable to environment, behavioral patterns, and genetic factors, which may all be subject to modification. [1],[2] Around 15% of the Middle Eastern population suffer from diagnosed myopia, which frequently stays uncorrected due to cultural disincentives. [3] Uncorrected myopia is a major reason for traffic accidents [4] and has also been reported for night myopia >0.75D in the region. Apart from the refractive impairment, axial myopia bears the risk of retinal detachment and is a potentially blinding condition.

Genetic research has resulted in the identification of linkage regions for myopia (2q, 4q, 7q, 12q, 15q,17q, 18p, 22q, and Xq), and genes on 7p15, 7q36, and 22q11 were reported to control myopia. [5] Only recently, research has focused on the vitamin D receptor wherein polymorphisms have been found associated with myopia. In the zebrafish, nonsense mutations in low-density lipoprotein receptor-related protein 2 (lrp2), which serves also as an endocytic receptor for the vitamin D binding protein, has been linked to the development of high myopia (and glaucoma). In humans, polymorphisms of the vitamin D receptor and the group-specific component were linked to moderate myopia, corroborating preliminary findings of lower vitamin D blood levels in myopes.

Besides other important articles in this issue of OJO, research reported on the vitamin D receptor gene start codon (fok1) further details the significance of vitamin D involvement in myopia and is another step on the long road to understanding genetics in myopia.

   References Top

1.Resnikoff R, Pascolini D, Mariotti SP, Pokharel GP. Global magnitude of visual impairment caused by uncorrected refractive errors in 2004. Bull World Health Organ 2008;86:63-706.   Back to cited text no. 1
2.WHO Prevention of Blindness and Visual Impairment: Priority eye diseases. Refractive errors and low vision. Available from: http://www.who.int/blindness/causes/priority/en/index5.html. [Last accessed on 2011].  Back to cited text no. 2
3.Khandekar R, Mohammed AJ, Al Raisi A. The compliance of spectacle wear and its determinants among school children of Dhakhiliya region of the Sultanate of Oman. A descriptive study. Sultan Qaboos Univ J Sci Res Med Sci 2002;4:39-42.  Back to cited text no. 3
4.Sagberg F. Driver health and crash involvement: A case-control study. Accid Anal Prev 2006;38:28-347.   Back to cited text no. 4
5.Klein AP, Duggal P, Lee KE, Cheng CY, Klein R, Bailey-Wilson JE, et al. Linkage analysis of Quantitative Refraction and Refractive Errors in the Beaver Dam Eye Study. Invest Ophthalmol Vis Sci 2011 May 12 [In Press].  Back to cited text no. 5

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