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Year : 2016  |  Volume : 9  |  Issue : 3  |  Page : 150-156

A comparative study of various topical nonsteroidal anti-inflammatory drugs to steroid drops for control of post cataract surgery inflammation

1 Department of Ophthalmology, Ndmc Medical College and Hindu Rao Hospital, Delhi, India
2 Department Of Ophthalmology, Llrm Medical College, Meerut, Uttar Pradesh, India

Correspondence Address:
Anu Malik
H. No. 584, Sri Nagar, Hapur, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-620X.192268

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Background: Postoperative inflammation continues to be a cause of patient discomfort, delayed recovery, and in some cases, suboptimal visual results. Topical nonsteroidal anti-inflammatory drugs (NSAIDs) and steroid are commonly used in the management and prevention of noninfectious ocular inflammation following cataract surgery. Aims: The aim was to study the safety and efficacy of various NSAIDs drops for control of postoperative inflammation following cataract surgery and compare with steroid eye drops in a patient following cataract surgery. Subjects and Methods: Totally, 200 patients undergoing phacoemulsification with posterior chamber intraocular lens implantation were randomly assigned to receive either nepafenac 0.1% 3 times daily, bromfenac 0.09% twice daily, ketorolac 0.5% 4 times daily for 1 month or 1% prednisolone eye drops as their postoperative anti-inflammatory medication with 50 cases in each group. The patients were examined at the 1 st day (baseline), 1 st week, 2 nd week, and 4 th week after surgery. Postoperative inflammation was evaluated subjectively by intraocular pressure, slit-lamp assessment of signs of inflammation, including conjunctival hyperemia, ocular pain, and aqueous cells and flare. Statistical Analysis: Statistical analysis was performed by the SPSS program for Windows, version 17.0. Results and Conclusions: In our study, we found that prednisolone 1% was more effective in controlling postoperative intraocular inflammation in terms of reducing anterior chamber cells and flare. We found that ketorolac 0.5% and nepafenac 0.1% were equally effective in controlling postoperative ocular pain and inflammation. All four drugs are effective in controlling post cataract surgery ocular inflammation. Intraocular inflammation is best controlled with prednisolone 1%, while ocular pain and hyperemia are better controlled with NSAIDs in the early postoperative periods.

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