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 Table of Contents    
Year : 2021  |  Volume : 14  |  Issue : 2  |  Page : 124-125  

Bilateral multiple iridociliary cysts causing secondary pigment dispersion

Glaucoma Department, Dr. Shroff Charity Eye Hospital, New Delhi, India

Date of Submission16-Jan-2021
Date of Acceptance21-May-2021
Date of Web Publication28-Jun-2021

Correspondence Address:
Dr. Prerna Garg
C-41, Greater Kailash-1, New Delhi - 110 048
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ojo.ojo_17_21

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Primary epithelial iris cysts are benign innocuous lesions, which are mostly bilateral and asymptomatic in nature. They can lead to creeping angle closure, when the angle progressively narrows due to age-associated changes. This photoessay, herewith, signifies the dual importance of identifying minute bumpy elevations in the iris by a thorough slit lamp examination as well as the use of ultrasound biomicroscopy in patients presenting with creeping angle closure, frequently misdiagnosed in the primary angle closure disease spectrum.

Keywords: Iris cysts, open angle, pigment dispersion, ultrasound biomicroscopy

How to cite this article:
Garg P, Dubey S, Mukherjee S, Daga D. Bilateral multiple iridociliary cysts causing secondary pigment dispersion. Oman J Ophthalmol 2021;14:124-5

How to cite this URL:
Garg P, Dubey S, Mukherjee S, Daga D. Bilateral multiple iridociliary cysts causing secondary pigment dispersion. Oman J Ophthalmol [serial online] 2021 [cited 2023 Mar 30];14:124-5. Available from: https://www.ojoonline.org/text.asp?2021/14/2/124/319482

   Introduction Top

A 45-year-old male presented with decrease in near vision. His best-corrected visual acuity was 6/6, N6 with correction. Slit lamp examination revealed multiple bumpy elevation of the peripheral iris in the nasal quadrant of the right eye and in the nasal [Figure 1] and temporal quadrants of the left eye. Rest of the ocular examination revealed no abnormal findings. In both eyes, gonioscopy revealed open angles with localized apposition between the iris and trabecular meshwork noted at the sites of bumpy elevation of the iris [Figure 2] and [Figure 3]. Trabecular meshwork pigmentation was 4+. There were broken pigments seen in the temporal angle in the right eye, signifying some degree of intermittent iridotrabecular contact in that quadrant [Figure 2].
Figure 1: The bumpy elevation in the nasal peripheral iris of the left eye

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Figure 2: Gonioscopic image of the right eye depicting open angles with localized apposition in areas of bumpy elevation and areas of broken pigments. Yellow arrow - Bumpy elevation of iris and localized apposition. Red arrow . Area of broken pigmentation

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Figure 3: Gonioscopic image of the left eye depicting open angles and localized apposition at site of bumpy elevation

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A provisional diagnosis of primary pigment epithelial cysts was made, and ultrasound biomicroscopy (UBM) was done to confirm the same. On UBM, multiple cystic spaces were seen behind the peripheral iris and in the ciliary sulcus [Figure 4]. These were seen in all the quadrants and in both eyes. All the cysts were thin walled and had no internal reflectivity with diameter varying from 2 mm to 1 cm. For academic purposes, anterior-segment optical coherence tomography (ASOCT) was done, but no pathological lesion was seen with this mode of investigation [Figure 5]. The angle anatomy, however, varied in different quadrants, with narrow angle width and convex iris configuration in some areas and normal-wide angle width with flat iris insertion in other areas. The bumpy appearance of the peripheral iris was visible with ASOCT similar to that on slit lamp; however, the anterior margin of the cysts was not discernable.
Figure 4: Ultrasound biomicroscopy image showing the extensive multiple thin-walled, cystic lesions beneath the mid peripheral and peripheral iris causing the bumpy elevation of the iris

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Figure 5: Anterior-segment optical coherence tomography image showing the irregular angle opening in different quadrants

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   Discussion Top

  • The above case describes the importance of a routine slit lamp evaluation in all patients. Further, with age-related changes in the angle and lens, this patient remains more prone to develop angle closure and subsequently glaucoma. UBM permits noninvasive examination of the anterior-segment anatomy at high resolution (40 μm) by using a high-frequency transducer.[1] Kunimatsu et al. performed UBM in eyes of 116 normal subjects and detected a surprisingly high incidence of cysts at 54.3%.[2] Wang and Yao conducted UBM in 727 patients with shallow anterior chambers.[3] They detected primary iris and ciliary body cysts in 34.4% of these patients, with secondary plateau iris configuration in 38%. The cysts larger than 0.8 mm, located at iridociliary sulcus, or multiple and extensive cysts were more inclined to cause angle narrowing or closure
  • Even though iris cysts are pathologically insignificant, early diagnosis by UBM remains helpful in identifying patients prone to develop angle closure, particularly when they are bilateral and multiple.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

   References Top

He M, Wang D, Jiang Y. Overview of ultrasound biomicroscopy. J Curr Glaucoma Pract 2012;6:25-53.  Back to cited text no. 1
Kunimatsu S, Araie M, Ohara K, Hamada C. Ultrasound biomicroscopy of ciliary body cysts. Am J Ophthalmol 1999;127:48-55.  Back to cited text no. 2
Wang BH, Yao YF. Effect of primary iris and ciliary body cyst on anterior chamber angle in patients with shallow anterior chamber. J Zhejiang Univ Sci B 2012;13:723-30.  Back to cited text no. 3


  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]


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