About OJO | Search | Ahead of print | Current Issue | Archives | Author Instructions | Reviewer Guidelines | Online submissionLogin 
Oman Journal of Ophthalmology Oman Journal of Ophthalmology
  Editorial Board | Subscribe | Advertise | Contact
https://www.omanophthalmicsociety.org/ Users Online: 1004  Wide layoutNarrow layoutFull screen layout Home Print this page  Email this page Small font size Default font size Increase font size


 
 Table of Contents    
CASE REPORT
Year : 2022  |  Volume : 15  |  Issue : 2  |  Page : 222-224  

Childhood hypertension, sixth nerve palsy, and renal artery stenosis


1 Department of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, New Delhi, India
2 Department of Ophthalmology, Lady Hardinge Medical College and Associated Hospitals, University of Delhi, Dr. RML Hospital and ABVIMS, New Delhi, India

Date of Submission20-May-2021
Date of Decision04-Aug-2021
Date of Acceptance12-Aug-2021
Date of Web Publication29-Jun-2022

Correspondence Address:
Dr. Zia Chaudhuri
Department of Ophthalmology, Lady Hardinge Medical College and Associated Hospitals, University of Delhi, Dr. RML Hospital and ABVIMS, New Delhi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ojo.ojo_161_21

Rights and Permissions
   Abstract 


This short report demonstrates an uncommon presentation of intracranial bleeding and sixth nerve palsy in a child with systemic hypertension due to long-standing unilateral renal artery stenosis of unknown etiology that resulted in contracture of the affected kidney and compensatory hypertrophy of the contralateral kidney. Structural renal damage and cardiac ventricular hypertrophy suggested the pathology and ensuing hypertension to be long-standing; however, renal function tests were normal at presentation. The importance of routine outpatient evaluation of systemic blood pressure in children, similar to adults, so as to diagnose and treat secondary hypertension and its causes early, before further systemic and neurological complications set in, is emphasized. The primary neuro-ophthalmological clinical presentation of the child with subsequent confluence of major pediatric domains of medicine, surgery, neurology, cardiology, nephrology, interventional radiology, and ophthalmology toward optimum multidisciplinary etiological and symptomatic management of the condition and its sequelae and subsequent rehabilitation is described.

Keywords: Cranial nerve palsy, hypertension, renal artery stenosis, renovascular hypertension, sixth nerve palsy


How to cite this article:
Madan S, Chaudhuri Z. Childhood hypertension, sixth nerve palsy, and renal artery stenosis. Oman J Ophthalmol 2022;15:222-4

How to cite this URL:
Madan S, Chaudhuri Z. Childhood hypertension, sixth nerve palsy, and renal artery stenosis. Oman J Ophthalmol [serial online] 2022 [cited 2022 Aug 15];15:222-4. Available from: https://www.ojoonline.org/text.asp?2022/15/2/222/348971




   Introduction Top


Hypertension is uncommon in the pediatric age group.[1] As blood pressure is rarely measured in children as a routine, this can remain undetected for long and may present with systemic and neurological sequelae, which can be life-threatening or may cause significant morbidity.[1] The reported case is unusual because of the unique association of increased intracranial tension (ICT) and sixth nerve palsy with secondary hypertension due to long-standing unilateral renal artery stenosis of unknown etiology. The satisfactory multidisciplinary management of the subject is also described.


   Case Report Top


An 8-year-old female child presented to the ophthalmology outpatient services with sudden-onset diplopia on the right gaze preceded by severe frontal headache, multiple episodes of projectile, nonbilious and nonblood-stained vomiting, one episode of generalized tonic–clonic seizure, and excessive drowsiness. There was no history of trauma.

On general physical examination, she weighed 19.5 kg (normal range for 8 years of age and female gender is about 25–28 kg). The blood pressure was 200 mmHg (systolic) and 120 mmHg (diastolic). The pulse was 96 per minute, regular, symmetrical, and with good volume.

On ophthalmic evaluation, the unaided visual acuity was 6/18 in the right eye and 6/12 in the left eye, with no improvement on pin-hole assessment or significant correctable refractive error in either eye. Pupillary reactions were equal to light and near evaluation in both eyes. There was an obvious esodeviation of the right eye with marked abduction deficit, suggestive of sixth nerve palsy. Diplopia charting confirmed this diagnosis. Visual field evaluation by confrontation as well as haploscopy tests for charting the range of extraocular muscle action was inconclusive at initial evaluation as the child was very drowsy and inconsistent with accurate replies. Fundus evaluation revealed bilateral extensive Grade IV hypertensive retinopathy with papilledema.

Contrast-enhanced computed tomography (CECT) scan of the head revealed intraparenchymal bleed in the right temporo-occipital lobe [Figure 1]a. As the child was drowsy, she was admitted to the pediatric intensive care unit and started on antihypertensive therapy comprising intravenous sodium nitroprusside (0.4 μg/ kg/min), intravenous furosemide (1.5 mg/kg three times daily [TDS]), and oral amlodipine (2.5 mg once a day [OD]) for emergency control of blood pressure, which finally stabilized after 24 h on oral doses of amlodipine (2.5 mg OD), atenolol (25 mg OD), prazosin (2 mg OD), and triamterene (25 mg twice daily [BD]). CT of the abdomen demonstrated a smoothly contracted right kidney with compensatory hypertrophy of the left kidney [Figure 1]b, coronal and c, axial]. The right renal artery was markedly constricted on CT angiography [Figure 1]d. Two-dimensional echocardiography showed left ventricular hypertrophy, possibly due to the severe and long-standing secondary systemic hypertension. Renal function tests were normal.
Figure 1: (a) Contrast enhanced axial computed tomography scan of the head demonstrated intraparenchymal bleed in the right parietooccipital lobe (white arrow). (b and c) Coronal and axial computed tomography scan of the abdomen revealed smoothly contracted right kidney (white arrow) and hypertrophied left kidney (black arrow). (d) Right renal artery stenosis was observed on computed tomography angiography (white arrow)

Click here to view


Successful balloon stenting and dilatation (2 cm × 12 mm) of the renal artery were performed. Four weeks later, the decreasing blood pressure stabilized at 130 mmHg (systolic) and 90 mmHg (diastolic) on no antihypertensive therapy. Over the next 3 months, gradual improvement of abduction movements in the right eye was observed till the movements became full [Figure 2]a and [Figure 2]b. The patient was patched in the right eye till then to avoid diplopia. The hypertensive retinopathy demonstrated no progression, and the papilledema decreased over the next 6 months [Figure 3]a and [Figure 3]b. A repeat CECT of the head after 6 months showed no evidence of the intraparenchymal bleed. The visual acuity improved to unaided 6/6 in both eyes. The patient maintained normal blood pressure on no medications, normal ocular movements, and no other neurological sequelae subsequently, over a follow-up of 2 years.
Figure 2: Pre (a) and post-treatment (b) photographs of the patient in 9 gazes demonstrating normalization of abduction movements in the right eye after antihypertensive therapy and balloon dilatation of the stenosed renal artery

Click here to view
Figure 3: Pre (a, top) and post-treatment (b, bottom) fundus photograph of the right and left eye of the patient demonstrating amelioration of the marked bilateral disc edema (white arrow) after treatment. The bilateral disc edema could have been a direct sequelae of severe systemic hypertension or, alternately, the sequelae of high intracranial tension and papilledema because of the intracranial bleed demonstrated in Figure 1a

Click here to view



   Discussion Top


Renal artery stenosis in children is uncommon and occurs due to congenital constriction of the affected renal artery. It may be the cause of renovascular hypertension.[1] Other reported acquired causes include the mid-aortic syndrome, phacomatosis syndromes such as the Klippel–Trenaunay  Weber syndrome More Details, linear sebaceous nevus syndrome (Jadassohn nevus phacomatosis) and neurofibromatosis, inflammatory vasculitis of large- and medium-sized blood vessels as in Takayasu's arteritis, Kawasaki disease, Crohn's disease and disseminated tuberculosis, as well as in collagen vascular diseases affecting large- and medium-sized blood vessels such as Marfan's syndrome and fibromuscular dysplasia.[2],[3],[4] Left untreated, renal artery stenosis in children may cause systemic hypertension associated with neurological sequelae such as stroke and seizures as well as failure to thrive and gradual renal failure, especially if the kidneys are affected bilaterally or if the unilateral stenosis is so severe that the contralateral kidney has to compensate and overwork, gradually taking the body into bilateral chronic renal failure. Fortuitously, for the child, in this report, the acute neuro-ophthalmological presentation of sixth nerve palsy, decrease in vision, bilateral Grade IV hypertensive retinopathy, and signs of increased ICT aided the discovery and management of this long-standing asymptomatic condition before the situation became irreversible in the form of cardiac or renal failure. Appropriate multidisciplinary management of the primary cause was helpful not only in the reversal of most of these systemic sequelae but also in rehabilitating the child toward a more productive and meaningful life. We emphasize that simple measures such as routine office evaluation of blood pressure in children would aid detect systemic hypertension and its causes in this age group before further progression of the condition and its neurological or other systemic sequelae occurs.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient (s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initial s will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Tullus K, Brennan E, Hamilton G, Lord R, McLaren CA, Marks SD, et al. Renovascular hypertension in children. Lancet 2008;371:1453-63.  Back to cited text no. 1
    
2.
Williams KM, Shah AN, Morrison D, Sinha MD. Hypertensive retinopathy in severely hypertensive children: Demographic, clinical, and ophthalmoscopic findings from a 30-year British cohort. J Pediatr Ophthalmol Strabismus 2013;50:222-8.  Back to cited text no. 2
    
3.
Bouziane Z, Boukhabrine K, Lahlou Z, Benzirar A, el Mahi O, Lekehal B, et al. Tuberculosis of the renal artery: A rare cause of renovascular arterial hypertension. Ann Vasc Surg 2009;23:9. e7-9.  Back to cited text no. 3
    
4.
Peco-Antić A, Stajić N, Krstić Z, Bogdanović R, Miloševski-Lomić G, Đukić M, et al. Associated extrarenal vascular diseases may complicate the treatment and outcome of renovascular hypertension. Acta Paediatr 2016;105:e35-41.  Back to cited text no. 4
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

Top
   
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
   Case Report
   Discussion
    References
    Article Figures

 Article Access Statistics
    Viewed116    
    Printed6    
    Emailed0    
    PDF Downloaded21    
    Comments [Add]    

Recommend this journal