Oman Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2009  |  Volume : 2  |  Issue : 2  |  Page : 73--78

Bevacizumab therapy for macular edema in central retinal vein occlusion: Long-term results


George J Manayath, V Narendran, Nadia Al-Kharousi, Upender K Wali 
 Vitreo-retina Unit, Aravind Eye Hospital, Coimbatore, India; Department of Ophthalmology, Sultan Qaboos University Hospital, Muscat, Sultanate Of Oman

Correspondence Address:
George J Manayath
Department of Ophthalmology, Sultan Qaboos University Hospital, Post Box: 38, Al Khod, Muscat, Sultanate Of Oman-123

Background: There is no proven effective treatment for vision loss in central retinal vein occlusion (CRVO). Bevacizumab has been reported in small series with limited follow-up, to have a positive effect in reducing cystoid macular edema (CME) and improving vision in CRVO. Purpose: To report long-term results with the use of bevacizumab in CRVO. Materials and Methods: Prospective interventional case series included 15 patients, serially evaluated with best corrected visual acuity (BCVA), optical coherence tomography (OCT), fluorescein angiography, and tonometry. Results were statistically analyzed. Results: Mean follow-up was 12 3.6 months (range, 6−18 months); mean number of injections was 2.2 (range, 1−4) per patient. Statistically significant reduction of macular thickness (P < 0.001) was seen at six weeks (mean, 346 ); three months (mean, 353 ); six months (mean, 348 ); and final follow-up (mean, 342 ). Significant BCVA improvement was seen at six weeks (mean, 0.27 logMAR), three months (mean, 0.3 logMAR), three months (0.15 logMAR), and final follow-up (mean, 0.21 logMAR) (P = 0.009). Also, 73.3% patients had BCVA improvement at the last follow-up. Conclusion: Intravitreal bevacizumab is an effective treatment option for CME in CRVO patients. Reinjections at appropriate timing, based on the OCT findings, are important for better visual outcome.


How to cite this article:
Manayath GJ, Narendran V, Al-Kharousi N, Wali UK. Bevacizumab therapy for macular edema in central retinal vein occlusion: Long-term results.Oman J Ophthalmol 2009;2:73-78


How to cite this URL:
Manayath GJ, Narendran V, Al-Kharousi N, Wali UK. Bevacizumab therapy for macular edema in central retinal vein occlusion: Long-term results. Oman J Ophthalmol [serial online] 2009 [cited 2022 Aug 9 ];2:73-78
Available from: https://www.ojoonline.org/article.asp?issn=0974-620X;year=2009;volume=2;issue=2;spage=73;epage=78;aulast=Manayath;type=0