Oman Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 4  |  Issue : 1  |  Page : 21--24

Role of antimetabolites in recalcitrant idiopathic orbital inflammatory syndrome


Yamini Priya, Suneetha Nithyanandam, Manjoo S Reddy 
 Department of Ophthalmology, St John's Medical College Hospital, Bangalore - 560 034, India

Correspondence Address:
Yamini Priya
Department of Ophthalmology, St John«SQ»s Medical College, Bangalore - 560 034
India

Background : High-dose systemic steroids are the primary modality of treatment for idiopathic orbital inflammatory syndrome (IOIS). Occasionally patients experience a relapse of symptoms on tapering steroids or require large doses of steroid, predisposing them to the adverse effects of steroids. Aim : We present our experience with the management of three patients with recalcitrant IOIS, with immunosuppressive therapy, using antimetabolites. Materials and Methods : A retrospective review of the medical records of the patients being reported. Results: Two patients were treated with Methotrexate and one with Azathioprine for a duration of 6-24 months. Two patients were symptom-free three years after stopping the medication. One was doing well clinically with methotrexate therapy alone, when he was lost to follow-up after six months. No adverse effects of immunosuppressive therapy were encountered. Conclusion : High-dose systemic steroid therapy is the first-line treatment for IOIS, but in refractory or steroid-dependent cases, immunosuppressive therapy with antimetabolites is a safe and effective treatment alternative to steroids. However, treatment with antimetabolites warrants close monitoring for complications like bone marrow suppression and liver dysfunction, especially because long-term treatment is required.


How to cite this article:
Priya Y, Nithyanandam S, Reddy MS. Role of antimetabolites in recalcitrant idiopathic orbital inflammatory syndrome.Oman J Ophthalmol 2011;4:21-24


How to cite this URL:
Priya Y, Nithyanandam S, Reddy MS. Role of antimetabolites in recalcitrant idiopathic orbital inflammatory syndrome. Oman J Ophthalmol [serial online] 2011 [cited 2022 Aug 18 ];4:21-24
Available from: https://www.ojoonline.org/article.asp?issn=0974-620X;year=2011;volume=4;issue=1;spage=21;epage=24;aulast=Priya;type=0